Who was Gossip Girl? The series finale told all


NEW YORK (AP) — "Gossip Girl" ended its six-season run with a major reveal: The identity of its tattle-tale blogger.


Known only as Gossip Girl and given narrative voice by actress Kristen Bell, she turned out to be a he. The Monday night finale revealed Gossip Girl was secretly the work of character Dan Humphrey.


Dan, played by Penn Badgley, was a budding poet and a student at Manhattan's posh St. Jude's Preparatory School for Boys. But he came from the other side of the tracks, or rather, from Brooklyn, across the East River.


His Gossip Girl blog was a sassy tell-all account of the lives of the privileged young adults who made up the CW drama. Other series stars included Blake Lively, Leighton Meester and Chace Crawford.


At the end, Dan fittingly pronounced Gossip Girl dead.


___


Online:


http://www.cwtv.com


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Attackers in Pakistan Kill Anti-Polio Workers





ISLAMABAD, Pakistan — Five Pakistani women and a man were killed on Tuesday in separate attacks on health workers participating in a national drive to eradicate polio from Pakistan.







Akhtar Soomro/Reuters

The bodies of two female workers with an anti-polio drive lay in the morgue at Jinnah Hospital in Karachi on Tuesday.







Athar Hussain/Reuters

Family members mourned the death of Nasima Bibi, a female worker with an anti-polio drive campaign in Pakistan, who was shot by gunmen on Tuesday.






The attacks forced health officials to temporarily suspend a large polio vaccination drive in Karachi, the country’s most populous city, where the disease has been making a worrisome comeback in recent years.


Saghir Ahmed, the health minister for southern Sindh Province, said he had ordered the 24,000 aid workers taking part in the campaign in Karachi to immediately stop work. It was not clear when they would resume.


The shooting represented a brutal setback to polio immunization efforts in Pakistan, one of just three countries in the world where the disease remains endemic. Pakistan accounted for 198 new cases last year — the highest rate in the world, followed by Afghanistan and Nigeria.


There was no immediate claim of responsibility, but Taliban insurgents have repeatedly vowed to target anti-polio workers, accusing them of being spies.


In the tribal areas along the Afghan border, Taliban leaders have issued religious edicts declaring that the United States runs a spy network under the guise of vaccination programs.


That perception was strengthened after the American commando raid that killed Osama bin Laden in June 2011, when it emerged that the Central Intelligence Agency had paid a Pakistani doctor to run a vaccination program in Abbottabad, where Bin Laden was hiding, in a bid to obtain DNA evidence from his family.


Pakistani authorities arrested the doctor, Shakil Afridi, shortly after the American raid, and he has been sentenced to 33 years in prison.


Despite the negative perceptions, the government has pressed ahead with a large polio vaccination campaign, usually conducted in three-day spurts involving tens of thousands of health workers who administer medicine to children under 5.


The shootings on Tuesday came on the second day of the latest drive, which has now been called off in Karachi. After an attack on a United Nations doctor from Ghana in Karachi last July, officials were braced for some sort of militant resistance. But the extent and scale of the attacks Tuesday caught the government by surprise.


In the attacks in Karachi, three teams of health volunteers were targeted in poor neighborhoods: Landhi, Orangi and Baldia Town.


Two female aid workers were killed in an attack in Landhi, according to local news reports. In Orangi, unknown gunmen opened fire on a health team, killing one woman and a male volunteer. Another female worker was killed in nearby Baldia Town.


The Karachi neighborhoods where aid workers were targeted Tuesday are being used as safe havens by militants, who have escaped American drone strikes in North and South Waziristan tribal regions, according to police officials. Security forces regularly conduct search operations in these neighborhoods.


In the northwestern city of Peshawar, gunmen riding a motorcycle opened fire on two sisters who had volunteered to help administer polio drops, killing one.


The attacks on polio workers followed a bold Taliban assault on a major Pakistan Air Force base in Peshawar over the weekend that killed at least 15 people and a militant bomb attack in a nearby tribal village on Monday that killed another 19.


For Pakistan’s beleaguered progressives, the attack on female health workers was another sign of how the country’s extremist fringe would stoop to attack the vulnerable and minorities.


“Ahmadis, Shias, Hazaras, Christians, child activists, doctors, anti-polio workers — who’s next on the target list, Pakistan?” asked Mira Hashmi, a lecturer in film studies at the Lahore School of Economics, in a post on Twitter.


Zia ur-Rehman contributed reporting from Karachi



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Amgen pleads guilty, to settle misbranding case for $762 million













Amgen


Drugmaker Amgen Inc. of Thousand Oaks reached a settlement Tuesday in a federal investigation of its sales and marketing practices.
(Paul Sakuma / Associated Press / December 17, 2012)































































Biotech giant Amgen Inc. pleaded guilty to a federal misdemeanor of misbranding its anemia drug Aranesp and has agreed to pay $762 million in fines and penalties.


The Thousand Oaks company said it had reached a preliminary settlement of federal criminal and civil investigations last year and had already set aside about $780 million to resolve several related cases.


A spokesman for the U.S. attorney's office in Brooklyn said a federal judge is scheduled to hold another hearing on the settlement Wednesday.





Amgen said the "plea and sentence remain subject to judicial review and approval" and it expects to resolve the related civil and criminal matters once that process is complete.


Federal prosecutors accused Amgen of promoting Aranesp for uses that weren't approved by the U.S. Food and Drug Administration, a common claim brought by government officials against big pharmaceutical companies.


Amgen's shares were up 7 cents to $89.57 in mid-session trading Tuesday.


Aranesp, which is used primarily to treat anemia in cancer patients, generated sales of $2.3 billion last year. But sales of Amgen's anemia treatments have slumped in recent quarters due partly to safety concerns.


In recent years, federal prosecutors have aggressively pursued whistleblower fraud cases against large drug makers and won major settlements.


In July, GlaxoSmithKline agreed to plead guilty to federal charges and pay $3 billion in the largest healthcare-fraud settlement in U.S. history.


However, some critics say the government's enforcement efforts don't go far enough since the company executives involved usually don't face significant penalties or jail time.


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Follow Chad Terhune on Twitter






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Fault lines also appearing on Democratic side in fiscal debate









WASHINGTON — For weeks, Democrats in Congress have been relishing the division and sniping within Republican ranks over whether to raise tax rates. But as negotiations over the budget crisis wear on and shift to a debate over spending cuts, the tables are turning.


Democrats last week aired their own internal battles in the war over the federal deficit. In a petition, a newspaper column, letters and sharply worded comments, top Democrats on Capitol Hill warned the president to protect the social safety net and step back from previous proposals to make major changes.


White House officials insist nothing is off the table, tacitly acknowledging that the president is weighing potential changes to Medicare, Medicaid and Social Security as he negotiates with House Speaker John A. Boehner (R-Ohio). Although both sides have been reluctant to put details in writing, any deficit reduction deal will almost certainly require significant alterations to these entitlement programs.





Boehner made a fresh offer in a phone call with the president Friday: The speaker would agree to allow tax rates to rise on those earning more than $1million in exchange for “substantial” reductions in spending and entitlements, according to an aide familiar with the negotiations who was not authorized to speak about the details.


Yielding on tax rates would be a substantial concession for the Republican leader, who had previously said that new revenue would come only from reforming the tax code next year in a way that could lower all rates. Democrats have dismissed that approach as not penciling out.


Boehner’s offer also could resolve the thorny issue of raising the nation’s debt limit, which will come up early next year. He wants to match new borrowing capacity with at least as much reduction in spending, but Democrats have resisted those efforts.


The White House does not appear to have accepted Boehner’s overture, although the lines of communication remain open.


“There is no agreement, nor is one imminent,” said Boehner spokesman Michael Steel over the weekend.


As for Democrats, the debate is the president’s first major postelection leadership challenge. It could determine not only whether a deal passes, but whether Obama can repair four years of ragged relations with his allies in Congress.


The debate is the president's first major postelection leadership challenge. It could determine not only whether a deal passes, but whether Obama can repair four years of ragged relations with his allies in Congress.


The Democratic fault lines were apparent last week. More than 80 Democrats signed a letter to Obama urging him not to agree to a deal that would raise the eligibility age for Medicare. Obama had moved in that direction last year in a failed attempt to craft a "grand bargain" with Boehner, considering an increase phased in over time.


"It will do great harm to our economy and millions of seniors to raise the Medicare eligibility age or enact other significant cost-shifting alternatives," the lawmakers wrote.


House Minority Leader Nancy Pelosi (D-San Francisco) was blunt. "Don't even think about raising the Medicare age," she said at a news conference Thursday, a day after an opinion piece she wrote appeared in USA Today. Pelosi left little wiggle room for the president, writing that raising the eligibility age "betrays the bedrock promise of Medicare."


Rep. Chris Van Hollen, the top Democrat on the House Budget Committee, has been in regular contact with administration officials involved in talks with Republicans. Van Hollen, of Maryland, said the White House was "doing a good job of keeping members of Congress informed consistent with the need to preserve the integrity of their discussions with the speaker," and that members "have confidence that the president is fighting for the priorities he talked about during the election."


"I should also say," he added, "we have let our members know that they should feel free to express their views directly to the president and to the White House, and they're doing that."


Democratic senators weighed in at a lunch Thursday with Gene Sperling, director of the White House's National Economic Council.


"We all understand compromise involves things we may not like — we understand that," Sen. Benjamin L. Cardin of Maryland said. "But I think there are certain parameters that we made pretty clear."


One is raising the Medicare eligibility age, now 65. Republicans have pushed to increase the age over time to 67. Sen. Richard J. Durbin of Illinois, the Senate's No. 2 Democrat, said that such a move was "not on the table."


Some Democrats, though, have signaled an openness to changes, such as charging higher Medicare premiums or curtailing health benefits for wealthier elderly people.


The White House sees the president's challenge as a matter of capitalizing on his reelection victory, convincing not only Republicans but also wary Democrats that Obama has a mandate to negotiate a deal that raises taxes on the wealthy and also cuts spending on entitlements.





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TV network aimed at millennials set for summer


NEW YORK (AP) — Participant Media plans to launch a cable network aimed at viewers 18 to 34 years old with programming it describes as inspiring and thought-provoking.


The as-yet-unnamed network is set to start next summer with an initial reach of 40 million subscribers, the company announced Monday.


Targeting so-called millennials, Participant is developing a program slate with such producers as Brian Graden, Morgan Spurlock and Brian Henson of The Jim Henson Company.


Evan Shapiro, who joined Participant in May after serving as President of IFC and Sundance Channel, will head the new network.


Parent company Participant Media has produced a number of fiction and nonfiction films including "Charlie Wilson's War," ''An Inconvenient Truth" and Steven Spielberg's current biopic "Lincoln."


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John Rosen, Doctor Who Pushed to Prevent Lead Poisoning, Dies at 77





Dr. John F. Rosen, a pediatrician whose discovery of high levels of lead poisoning among the New York City children he treated propelled him to campaign for a national effort to prevent the condition, died on Dec. 7 in Greenwich, Conn. He was 77.




The cause was colon cancer, his wife, Margaret, said.


When he arrived at Montefiore Medical Center in the Bronx in 1969, Dr. Rosen was mainly interested in how children’s bodies absorb calcium. But within a few years, concerned about the levels of lead he was seeing in his young patients and knowing that lead poisoning diminished mental capacities irreversibly, he embarked on a mission. Dr. Rosen helped establish one of the nation’s first and largest clinics for the treatment of lead poisoning; he personally supervised the treatment of 30,000 children. In one advance, he developed X-ray techniques for measuring lead in children’s bodies.


He went on to push New York City to adopt stricter standards for removing lead paint from tens of thousands of older buildings. (The use of lead paint had been outlawed in 1978.) In 1991 he led a committee at the Centers for Disease Control and Prevention in Atlanta that lowered the threshold at which children are considered to be poisoned by lead, to 10 micrograms per deciliter of blood from 60 micrograms.


But even that threshold was too high, Dr. Rosen believed, and he immediately began lobbying to reduce it further. This year, the C.D.C. halved it to 5 micrograms. The change could not help those who had lead in their bodies, but it sounded an alarm that even infinitesimal quantities of lead could be dangerous.


“It’s about time,” Dr. Rosen said.


He cited his own and others’ studies showing that lead poisoning harms a person’s ability to think and plan, as well as physical coordination. For a child with an I.Q. of 85, he said, lead exposure “could mean the difference between a menial job in a fast-food restaurant or a meaningful career.”


Dr. Rosen’s ambition was to eventually eradicate lead poisoning by eliminating exposure to lead altogether, in the manner that vaccines reduced the incidence of polio to almost none. He served on committees of the National Academy of Sciences and urged spending tens of billions of dollars to remove old lead paint from tens of millions of homes, calculating that lead exposure harmed far more children than asbestos.


Landlords and some government officials disputed the need for such a large-scale effort, arguing that lead poisoning had dropped sharply in recent decades as lead was removed from gasoline and that the use of lead paint had abated.


Dr. Rosen often testified in suits against property owners, leading some to suggest that his crusade was motivated by the prospect of personal financial gain from payments by plaintiffs’ lawyers.


He also had critics in the news media. In 2003 Andrew Wolf, then a columnist for The New York Sun, argued that the war against lead poisoning had been won and accused Dr. Rosen of practicing political, not medical, science. In 1992, Newsday questioned whether he was a “well-meaning prophet or merely an alarmist.”


Dr. Rosen replied: “I am not an alarmist. I cannot keep quiet when kids’ futures are at stake.”


John Friesner Rosen was born in Manhattan on June 3, 1935. His parents volunteered for civil rights and leftist causes and traveled to China to meet with Chou En-lai before President Richard M. Nixon’s historic trip there in 1972.


Dr. Rosen graduated from Harvard and the College of Physicians and Surgeons of Columbia University, did his residency at the Columbia-affiliated Babies Hospital and became a researcher at Rockefeller University. He moved on to Montefiore, where he became a pediatrics professor and head of environmental sciences at its Children’s Hospital. His focus was underprivileged children living in substandard housing.


In one instance, he encountered two young sisters who had made repeated visits to the hospital with very high levels of lead in their blood. He decided to accompany them home, but the home, he discovered, had been inspected and the paint found safe. He then accompanied them to a park, where they climbed up and down a fence. It was covered with lead paint.


Dr. Rosen started his lead clinic in the early 1970s. He later opened “safe houses,” where families could come while lead paint was removed from their homes. When lead paint was discovered in a Manhattan elementary school in 1992, he spoke out, calling the school “a toxic dump.” It was closed for a cleanup.


Dr. Rosen lived in Stamford, Conn. His first marriage, to Katharine Lardner, ended in divorce. He is survived by his wife, the former Margaret Hiatt; two children from his first marriage, Carlo, a physician, and Ellis Lesser; a daughter from his second marriage, Emily Reilly; and nine grandchildren.


Dr. Rosen’s concerns about lead poisoning went beyond residents of low-income housing. In 1988, he warned against eating Florida grapefruits because they had been sprayed with lead arsenate to speed ripening. Two years later, he reported seeing 30 or 40 cases of lead poisoning each year among children of wealthy people who had bought and restored brownstones.


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Santa Ana-based Edison Mission Energy files for bankruptcy









Edison Mission Energy, an unregulated power-generating unit of Rosemead-based Edison International, said Monday that it had filed for bankruptcy and had agreed on a reorganization plan with its parent company and holders of its $3.7 billion in debt.


 “We are pleased to have reached this agreement, which we believe reflects the long-term value potential of our organization,” Pedro Pizarro, president of Edison Mission Energy, said in a statement. “This is an important first step in the process to reduce our debt, enhance our liquidity profile and position EME for continued operation and future success."


As part of the deal, Edison Mission Energy will be deconsolidated from Edison International “as of the filing date” and, in the future, will be referred to by the parent company as discontinued operations.





Edison International’s stake in the bankrupt generating unit will be transferred to unsecured creditors.


Santa Ana-based Edison Mission Energy said it had slightly more than $5.1 billion in assets and just under that amount in liabilities in Chapter 11 papers filed Monday in the U.S. Bankruptcy Court in the Northern District of Illinois.


Edison Mission Energy has been struggling on several fronts: depressed energy prices because of the nation’s boom in natural gas production; higher fuel costs affecting its older coal-fired facilities; and pending debt maturities.


The company also said, in the statement, that it faced the “need to retrofit its coal-fired facilities to comply with environmental regulations.”


Despite the challenges, Pizarro sought to strike a positive tone on Edison Mission Energy’s future.


“We believe this financial restructuring — coupled with the existing strength of our employees and assets — will position us to take advantage of new opportunities while preserving our focus on safe, reliable operations,” Pizarro said.


Edison Mission Energy companies own, operate and lease a portfolio of more than 40 electric generating sites around the U.S. that are powered by wind, natural gas, biomass and coal, as well as an energy marketing and trading operation based in Boston.


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Speculation over autism, but shooter's 'why' has no easy answer









Among the details to emerge in the aftermath of the Connecticut elementary school massacre was the possibility that the gunman had some form of autism.


Adam Lanza, 20, had a personality disorder or autism, his brother reportedly told police. Former classmates described him as socially awkward, friendless and painfully shy.


While those are all traits of autism, a propensity for premeditated violence is not. Several experts said that at most, autism would have played a tangential role in the mass shooting -- if Lanza had it at all.





FULL COVERAGE: Connecticut school shooting


“Many significant psychiatric disorders involve social isolation,” said Catherine Lord, director of the Center for Autism and the Developing Brain at New York-Presbyterian Hospital.


Autism, she said, has become a catch-all term to describe anybody who is awkward.


Some type of schizophrenia, delusional disorder or psychotic break would more clearly fit the crime, experts said.


The hallmark characteristics of autism are social inability, communication problems and repetitive behaviors or obsessive interests. It emerges in early childhood and exists on a vast spectrum, from those who bang their head against the wall to those who can recite train schedules from memory.


PHOTOS: Connecticut school shooting


The rate of autism has skyrocketed over the last two decades, largely because of an expanded definition of the disorder and increasing awareness. The U.S. Centers for Disease Control and Prevention estimates that 1 in 88 children have it.


Researchers have struggled to draw clear lines between the various forms. As a result, the American Psychiatric Assn. is folding all of its varieties into a single diagnosis next year: autism spectrum disorder.


It will include people with Asperger’s syndrome -- the higher-functioning type that Lanza was most likely to have had.


There is more aggression associated with autism than with other disabilities. But it usually amounts to a tantrum and does not involve planning, weapons or an intention to harm anybody.


People with autism are more likely to be victims of violence than perpetrators. Those who are bright -- as Lanza was by several accounts -- often face bullying.


Some wind up in trouble with the law because they are unaware of social convention, and quirkiness or attempts at being friendly get misinterpreted.


Dr. John Constantino, an autism specialist at Washington University in St. Louis, said the social detachment and withdrawal associated with the disorder can accentuate other psychiatric conditions that are connected to violence.


And the feelings of isolation often intensify after high school, with the loss of a structured environment that allows many people with autism to stay afloat.


“They sort of fall off this cliff when they don’t have a village,” Constantino said.


Lanza finished high school early and was living with his mother. Police said he was disturbed by the divorce of his parents in 2009.


None of that, of course, explains why his killed his mother, 20 elementary school students, six women at the school and then himself.


“The only way somebody could do something like this is if they totally lost touch with reality,” said Dr. Daniel Geschwind, an autism expert at UCLA. “Autistic people are not sociopaths.”


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alan.zarembo@latimes.com



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Springsteen, Gaga join Stones; Newtown noted


NEW YORK (AP) — Only at a Rolling Stones concert could appearances by Bruce Springsteen and Lady Gaga seem almost like afterthoughts.


Those superstars and other top acts including the Black Keys and John Mayer jammed with the Stones on Saturday night, winding down a series of concerts celebrating the 50th year of rock's most enduring band (the occasion was also marked by a pay-per-view special).


The Boss rocked out with the band on out "Tumbling Dice"; Gaga matched Mick Jagger shimmy-for-shimmy on "Gimme Shelter"; the Black Keys joined on "Who Do You Love," and John Mayer and Gary Clark Jr. showed their considerable guitar chops alongside Keith Richards and Ronnie Wood on "Goin' Down."


But the Stones would not be upstaged. While the sold-out crowd roared with each special guest, it was the aging but dynamic foursome that generated the most excitement of the night, as they put new energy into their decades-old catalog of hits, including "It's Only Rock 'N Roll (But I Like It)," ''Start Me Up," ''Brown Sugar," ''Sympathy for the Devil" and more.


The band took a moment to acknowledge the shooting deaths of 20 children and six adults at an elementary school Friday in Newtown, Conn. "We just wanted to send our love and condolences to all the people who lost loved ones in the tragedy in Connecticut," Jagger early on in the concert as the audience applauded. Jagger noted the entire world was feeling the pain of the stunned nation.


But it was the only somber moment in an a frenetic show that showed why the Stones are considered by many to be the greatest rock band, and belied the much-discussed advanced age of the group's lineup (their ages range between 65 and 71).


Jagger himself poked fun at the senior citizen status of the band and their fans; speaking of the pay-per-view crowd at home, he joked: "Some of you have got your grandchildren watching you."


But few acts in their so-called prime would have been able to match the energy the Stones radiated onstage. The group had the crowd on its feet for the entire show as Jagger gyrated across the stage, his voice in top form. Both Wood and Richards dazzled on guitar (Richards got a raucous, sustained ovation as he took over vocals on two songs). And Charlie Watts kept the beat strong on the drums.


Before performing in London together late last month for the first of the concerts, the Stones hadn't performed in concert together since 2007. Going into these shows, there was some speculation that Saturday's concert, held at the Prudential Center, might be their last.


Earlier in the evening, Jagger teased that the concert might signal the end: "This could be the last time; I don't know," he said. But by the end of the evening, it seemed clear that the question was not when the Stones would return, but when.


"This is the last show of our anniversary tour, and we hope to see you all again soon," Jagger said.


Perhaps the night's most special guest was Mick Taylor, the former Stones guitarist who was part of some of their biggest moments from 1969 to 1975, when he left the group. He rejoined his band mates (and the man who replaced him, Wood) onstage for a powerful performance of "Midnight Rambler".


At the concert's end, while other special guests gave their final bows and left the stage, Jagger motioned for Taylor to stay, and the five took their final bow together.


___


Nekesa Mumbi Moody is the AP's Global Entertainment & Lifestyles Editor. Follow her at http://twitter.com/nekesamumbi


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Dr. William F. House, Inventor of Cochlear Implant, Dies





Dr. William F. House, a medical researcher who braved skepticism to invent the cochlear implant, an electronic device considered to be the first to restore a human sense, died on Dec. 7 at his home in Aurora, Ore. He was 89.




The cause was metastatic melanoma, his daughter, Karen House, said.


Dr. House pushed against conventional thinking throughout his career. Over the objections of some, he introduced the surgical microscope to ear surgery. Tackling a form of vertigo that doctors had believed was psychosomatic, he developed a surgical procedure that enabled the first American in space to travel to the moon. Peering at the bones of the inner ear, he found enrapturing beauty.


Even after his ear-implant device had largely been supplanted by more sophisticated, and more expensive, devices, Dr. House remained convinced of his own version’s utility and advocated that it be used to help the world’s poor.


Today, more than 200,000 people in the world have inner-ear implants, a third of them in the United States. A majority of young deaf children receive them, and most people with the implants learn to understand speech with no visual help.


Hearing aids amplify sound to help the hearing-impaired. But many deaf people cannot hear at all because sound cannot be transmitted to their brains, however much it is amplified. This is because the delicate hair cells that line the cochlea, the liquid-filled spiral cavity of the inner ear, are damaged. When healthy, these hairs — more than 15,000 altogether — translate mechanical vibrations produced by sound into electrical signals and deliver them to the auditory nerve.


Dr. House’s cochlear implant electronically translated sound into mechanical vibrations. His initial device, implanted in 1961, was eventually rejected by the body. But after refining its materials, he created a long-lasting version and implanted it in 1969.


More than a decade would pass before the Food and Drug Administration approved the cochlear implant, but when it did, in 1984, Mark Novitch, the agency’s deputy commissioner, said, “For the first time a device can, to a degree, replace an organ of the human senses.”


One of Dr. House’s early implant patients, from an experimental trial, wrote to him in 1981 saying, “I no longer live in a world of soundless movement and voiceless faces.”


But for 27 years, Dr. House had faced stern opposition while he was developing the device. Doctors and scientists said it would not work, or not work very well, calling it a cruel hoax on people desperate to hear. Some said he was motivated by the prospect of financial gain. Some criticized him for experimenting on human subjects. Some advocates for the deaf said the device deprived its users of the dignity of their deafness without fully integrating them into the hearing world.


Even when the American Academy of Ophthalmology and Otolaryngology endorsed implants in 1977, it specifically denounced Dr. House’s version. It recommended more complicated versions, which were then under development and later became the standard.


But his work is broadly viewed as having sped the development of implants and enlarged understanding of the inner ear. Jack Urban, an aerospace engineer, helped develop the surgical microscope as well as mechanical and electronic aspects of the House implant.


Karl White, founding director of the National Center for Hearing Assessment and Management, said in an interview that it would have taken a decade longer to invent the cochlear implant without Dr. House’s contributions. He called him “a giant in the field.”


After embracing the use of the microscope in ear surgery, Dr. House developed procedures — radical for their time — for removing tumors from the back portion of the brain without causing facial paralysis; they cut the death rate from the surgery to less than 1 percent from 40 percent.


He also developed the first surgical treatment for Meniere’s disease, which involves debilitating vertigo and had been viewed as a psychosomatic condition. His procedure cured the astronaut Alan B. Shepard Jr. of the disease, clearing him to command the Apollo 14 mission to the moon in 1971. In 1961, Shepard had become the first American launched into space.


In presenting Dr. House with an award in 1995, the American Academy of Otolaryngology-Head and Neck Surgery Foundation said, “He has developed more new concepts in otology than almost any other single person in history.”


William Fouts House was born in Kansas City, Mo., on Dec. 1, 1923. When he was 3 his family moved to Whittier, Calif., where he grew up on a ranch. He did pre-dental studies at Whittier College and the University of Southern California, and earned a doctorate in dentistry at the University of California, Berkeley. After serving his required two years in the Navy — and filling the requisite 300 cavities a month — he went back to U.S.C. to pursue an interest in oral surgery. He earned his medical degree in 1953. After a residency at Los Angeles County Hospital, he joined the Los Angeles Foundation of Otology, a nonprofit research institution founded by his brother, Howard. Today it is called the House Research Institute.


Many at the time thought ear surgery was a declining field because of the effectiveness of antibiotics in dealing with ear maladies. But Dr. House saw antibiotics as enabling more sophisticated surgery by diminishing the threat of infection.


When his brother returned from West Germany with a surgical microscope, Dr. House saw its potential and adopted it for ear surgery; he is credited with introducing the device to the field. But again there was resistance. As Dr. House wrote in his memoir, “The Struggles of a Medical Innovator: Cochlear Implants and Other Ear Surgeries” (2011), some eye doctors initially criticized his use of a microscope in surgery as reckless and unnecessary for a surgeon with good eyesight.


Dr. House also used the microscope as a research tool. One night a week he would take one to a morgue for use in dissecting ears to gain insights that might lead to new surgical procedures. His initial reaction, he said, was how beautiful the bones seemed; he compared the experience to one’s first view of the Grand Canyon. His wife, the former June Stendhal, a nurse, often helped.


She died in 2008 after 64 years of marriage. In addition to his daughter, Dr. House is survived by a son, David; three grandchildren; and two great-grandchildren.


The implant Dr. House invented used a single channel to deliver information to the hearing system, as opposed to the multiple channels of competing models. The 3M Company, the original licensee of the House implant, sold its rights to another company, the Cochlear Corporation, in 1989. Cochlear later abandoned his design in favor of the multichannel version.


But Dr. House continued to fight for his single-electrode approach, saying it was far cheaper, and offered voluminous material as evidence of its efficacy. He had hoped to resume production of it and make it available to the poor around the world.


Neither the institute nor Dr. House made any money on the implant. He never sought a patent on any of his inventions, he said, because he did not want to restrict other researchers. A nephew, Dr. John House, the current president of the House institute, said his uncle had made the deal to license it to the 3M Company not for profit but simply to get it built by a reputable manufacturer.


Reflecting on his business decisions in his memoir, Dr. House acknowledged, “I might be a little richer today.”


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